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Of Mice and Men - a good news story?
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Of Mice and Men - a good news story?
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Medicine, as we know, is littered with false prophets or the next great hope which the crashes and burns. It's also commonly said that the worst thing you can do with a cancer patient is take away ho
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Forums  »  Open clinical  »  General clinical  »  Of Mice and Men - a good news story?

Of Mice and Men - a good news story?

posted at 24/12/2012 10:23 AM GMT on bmj.com
Posts: 1264
First: 13/4/2010
Last: 20/5/2013

Medicine, as we know, is littered with false prophets or the next great hope which the crashes and burns.
It's also commonly said that the worst thing you can do with a cancer patient is take away hope. But it's not. The worst thing you can do is to offer false hope.
But every once in a while something comes along which actually manages to break through my barrier of extreme scepticism and pricks my curiosity.
And so it was with this story on the BBC yesterday:

http://www.bbc.co.uk/news/health-20795977

In essence researchers have managed to piggy-back cancer killing viruses onto macrophages. These macrophages flood tumours following radiotherapy or chemotherapy and in so doing they carry the viruses, Trojan Horse-like, into the heart of a tumour.
Experiments with prostate cancer in mice showed complete tumour eradication in the virus-treated subjects.
Another false dawn? Time will tell. But this time I have more hope than usual...

Re: Of Mice and Men - a good news story?

posted at 25/12/2012 9:37 AM GMT on bmj.com
Posts: 2044
First: 12/3/2010
Last: 21/5/2013
Sounds a good idea, steve, but using viruses to insert DNA into deficient cells was the lighthouse for gene therapy a short while ago, and led to some disasters.   There have been other ideas to get lymphocytes to carry chemo agents into tumours, releasing their package only 'on target' that AFAIK hasn't taken over chemotherapy.
No doubt all these ideas will find a place in the oncologists' cook book, but won't provide a new kitchen.

JOhn

Forums » Open clinical » General clinical » Of Mice and Men - a good news story?