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Does depot treatment for alcoholism work?
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Does depot treatment for alcoholism work?
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I am seeing a young Polish gentleman tomorrow , who has episodic alcoholism, he is sober for months , then drinks huge amounts for weeks. He sometimes stops after he wakes up in Hospital having had an
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Does depot treatment for alcoholism work?

posted at 6/8/2012 10:45 AM BST on bmj.com
Posts: 346
First: 17/12/2011
Last: 15/6/2013
I am seeing a young Polish gentleman tomorrow , who has episodic alcoholism, he is sober for months , then drinks huge amounts for weeks. He sometimes stops after he wakes up in Hospital having had an epileptic fit. His sister in law suggests taking him to Poland where they sometime put a depot injection that 'stops you  drinking alcohol'. I presume this is  Naltraxone like, or does anyone know of any other depot injection for alcoholism that works?

Re: Does depot treatment for alcoholism work?

posted at 6/8/2012 12:25 PM BST on bmj.com
Posts: 607
First: 8/6/2011
Last: 17/6/2013
Hello Pat.

I have not experience in depot injections for alcoholism, but what i know is that anonymous alcoholics are doing a great job . 
 
Why you don't give them a call ( to his doctors in poland )  and speak with them and ask exactly what substance is in this depot injections and how it works ?

Re: Does depot treatment for alcoholism work?

posted at 6/8/2012 7:42 PM BST on bmj.com
Posts: 346
First: 17/12/2011
Last: 15/6/2013

Thanks, I think he speaks no English but I will probably use telephone translation service. He may or may not turn up, one of the joys of inner city practice. I may post later in the week. I hope to get some of the last weekend of the London Olympicsin London, and an informal [pub]  KCS reunion. At the two events I have been at  [Earls Court volley ball and Cardiff football] one of the best things have been the crowds!

Re: Does depot treatment for alcoholism work?

posted at 8/8/2012 11:18 AM BST on bmj.com
Posts: 346
First: 17/12/2011
Last: 15/6/2013

I have now seen this gentleman, I have sent him to the local hospital, I have asked if the on call psychiatry team can see him. I think he ideally needs in patient detoxification, but I am not optimistic that he will get this. I have now seen another Polish lady who's husband is an alcoholic and via the telephone translation service and the internet ,i have learnt a bit more about depot Disulfiram [Antabuse].
From Wikipedia  [!], Disulfuram invented in 1948 by Danish drug company when looking for a remedy for parasitic infections !
It seem that in some eastern European counties , particularly in Poland disulfiram implants are popular for treating alcoholism. Disulfiram does not take away the alcohol cravings , but makes one vomit and feel very ill if you drink any alcohol.
The depot method involves ten 100mg pellets in a glass container that are implanted deep in the buttock, trade name Esperol. I understand that the cost of the procedure is about 300 pounds , so cheaper that naltroxone depo injections.

I don't suppose anyone in Doc to Doc community know if these implants work at prolonguing abstinence. As far as I know they are not available in the uk.

Re: Does depot treatment for alcoholism work?

posted at 8/8/2012 2:06 PM BST on bmj.com
Posts: 1012
First: 15/7/2011
Last: 15/6/2013
Pat, I lived for a few years in Finland where alcoholism is a very serious problem indeed. I remember speaking to a Consultant Psychiatrist who was a specialist in addiction - which almost invariably was Alcohol. He said that Disulfiram pellets are injected subcutaneously into the abdoment and if alcohol is ingested (as you suggest) the patient experiences a very unpleasant reaction which ranges from relatively mild to potentially fatal if alcohol is continuously ingested despite the start of a negative reaction.  The specialist told me that it allowed prolonged periods of abstinence usually in months to years - but when the Disulfiram was removed or became inneffective there were frequent relapses. Whilst it did not produce a cure, the prolonged abstinence was very beneficial for the patient in terms of personal and family relationships, maintaining work and close working with alcohol counsellors. Incidentally he also told me that the Antabuse tablets produce just the same reaction. He would get the patient to take the first 3 tablets in front of him in his office - apparently that guaranteed at least 2-3 weeks of  abstinence due to the prolonged effect of Disulfiram. As you know Pat I am not a Doctor but just thought the story might perhaps help.

Re: Does depot treatment for alcoholism work?

posted at 21/8/2012 7:03 AM BST on bmj.com
Posts: 6
First: 4/8/2012
Last: 4/9/2012
Alcohol dependence can be treated by rehabilitation and medication. In some cases, oral medication does not achieve optimum therapeutic effect and in some cases this may be related to poor compliance in taking an oral drug. Naltrexone is an opioid antagonist however the neurobiological mechanism by which it reduces alcohol consumption in alcohol dependent patients is not entirely understood.

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