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Clarithromycin verses Azithromycin
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Clarithromycin verses Azithromycin
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How to select one out of these two? Which micro-organisms are covered by one but not by the other?
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Clarithromycin verses Azithromycin

posted at 31/7/2011 9:28 AM BST on bmj.com
Posts: 220
First: 10/12/2010
Last: 1/6/2012

How to select one out of these two? Which micro-organisms are covered by one but not by the other?

Re: Clarithromycin verses Azithromycin

posted at 1/8/2011 11:21 AM BST on bmj.com
Posts: 1177
First: 19/4/2010
Last: 16/5/2013
Off at a tangent, a bit, but we recently ahd to decide which to recommend as our long term macrolide for anti-inflammatory therapy and exacerbation reduction in non-CF bronchiectasis.  Clearly it's an evidence vacuum, so we had to make a pragmatic choice.

We went for Clari as it's much cheaper.

I've only prescribed azithromycin to patients with CF in the past 5 years.

Re: Clarithromycin verses Azithromycin

posted at 1/8/2011 5:02 PM BST on bmj.com
Posts: 640
First: 2/2/2011
Last: 18/5/2013
i do remember a comments from an ophthalmologist that Azithromycine gives better results in certain bacteriological conditions affecting eyes.

Re: Clarithromycin verses Azithromycin

posted at 1/8/2011 5:29 PM BST on bmj.com
Posts: 492
First: 12/7/2010
Last: 7/5/2013
In Response to Re: Clarithromycin verses Azithromycin:
Off at a tangent, a bit, but we recently ahd to decide which to recommend as our long term macrolide for anti-inflammatory therapy and exacerbation reduction in non-CF bronchiectasis.  Clearly it's an evidence vacuum, so we had to make a pragmatic choice. We went for Clari as it's much cheaper. I've only prescribed azithromycin to patients with CF in the past 5 years.
Posted by DundeeChest

Here in India, azithromycin is much cheaper than clarithromycin and more commonly used than clarithromycin. I wonder why the pricing is reversed.

Re: Clarithromycin verses Azithromycin

posted at 2/8/2011 12:48 PM BST on bmj.com
Posts: 1177
First: 19/4/2010
Last: 16/5/2013
In Response to Re: Clarithromycin verses Azithromycin:
In Response to Re: Clarithromycin verses Azithromycin : Here in India, azithromycin is much cheaper than clarithromycin and more commonly used than clarithromycin. I wonder why the pricing is reversed.
Posted by Deb_D

Azithromycin is still on-patent, and clarithromycin is available as a generic....


Re: Clarithromycin verses Azithromycin

posted at 2/8/2011 4:40 PM BST on bmj.com
Posts: 220
First: 10/12/2010
Last: 1/6/2012
1-Azithrocin is cheaper than clarithromycin in Pakistan.
2-It is once a day
3-It covers all micro-organisms, covered by clarithromycin, and others including salmonella typhi and parathypi. ( this is the point I request elaboration).
4-In respiratory tract infections, 3 dose in 3 days covers for next 7-10 days.

5- Still why clarithromycin?

Re: Clarithromycin verses Azithromycin

posted at 2/8/2011 5:19 PM BST on bmj.com
Posts: 640
First: 2/2/2011
Last: 18/5/2013
if the practitioners themselves do not try to evaluate / judge the efficacy of a drug they prescribed on daily basis then otherwise face the interpretations of a drug the business enterprises put before you.

Re: Clarithromycin verses Azithromycin

posted at 2/8/2011 5:56 PM BST on bmj.com
Posts: 2
First: 2/8/2011
Last: 2/8/2011
In cases of LRTI, where the macrolide is not the drug of choice, Clarithromycin offered better symptomatic relief than Azithromycin.
Proprietary brands of Azithromycin, of course, happen to be cheaper than that of Clarithromycin.

Re: Clarithromycin verses Azithromycin

posted at 3/8/2011 12:10 PM BST on bmj.com
Posts: 1177
First: 19/4/2010
Last: 16/5/2013
We don't use Macrolides as first, or second line treatment for LRTI, so the question is mute for us.  We *do* give macrolides for their anti-inflammatory activity, so in this evidence free zone we go for the cheaper option.  The spectrum of coverage, length of treatment etc are all irrelevant.

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