Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
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Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
Discuss any aspect of type I or type II diabetes mellitus here
There are times when a really important paper is published with a really obscure title. This paper that was just published in Nature is one of these times http://www.nature.com/nature/journal/va
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Cat:OpenClinicalForum:209c1fee-a6e1-4cf9-9bd5-7d4dd5443e39
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Forums » Open clinical » Diabetes » Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
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Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
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Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
posted at 13/1/2012 7:10 PM GMT
on bmj.com
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Posts: 142
First: 29/4/2011 Last: 14/5/2012 |
There are times when a really important paper is published with a really obscure title. This paper that was just published in Nature is one of these times http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10777.html Here is the abscract: Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Irisin acts on white adipose cells in culture and in vivo to stimulate UCP1 expression and a broad program of brown-fat-like development. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise. I would like to take credit for finding this gem of an article, but in truth it was the New York Times' health page that featured it Wednesday http://well.blogs.nytimes.com/2012/01/11/exercise-hormone-helps-keep-us-healthy/ Basically people who exercise regularly are less obese and less prone to diabetes. There has developed a body of thought that muscle cells must in some way communicate with fat cells, but until now the messinger has been unidentifided. This paper describes the messinger, Irisin, and provides substantial evidence that its effect is to change the metabolism of typical fat cells into the hypermetabolic brown fat cells. its name by the way suggests that Harvard physicians still receive a classic education. if you are not up-to-date on your Greek methology, the Times article will enlighten you. |
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Re: Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
posted at 13/1/2012 8:36 PM GMT
on bmj.com
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Posts: 1317
First: 7/3/2009 Last: 15/5/2012 |
Will brown hypermetabolic fat cells change back to white fat cells once we stop adminstration of irisin? Some sportsmen who stop training become overweight, and the question is is this just due to a more sedentary lifestyle, more food intake. Or might it also be that their irisin levels drop and their brown fat cells change into white fat cells?
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Re: Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
posted at 14/1/2012 1:17 AM GMT
on bmj.com
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Posts: 2072
First: 10/3/2009 Last: 16/5/2012 |
Very interesting. We see brown fat particularly around the shoulder girdles on FDG-PET scans. Babies have a lot of brown fat and I think, hibernating animals. DiabetesMD can you give me the Ladybird Book version of brown fat versus white fat. Why is it still there in us as adults, why in the shoulder girdle and should I hibernate each winter? Has anyone done studies on brown fat in sleep apnoea? Is it more common in adults in certain racial groups? Fat is clearly sexy. The browner the better.
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Re: Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
posted at 29/1/2012 12:46 PM GMT
on bmj.com
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Posts: 142
First: 29/4/2011 Last: 14/5/2012 |
While I am not a brown fat guru, i do not beleive that the life styles of brown fat in human adults are clear. The issue of atheletes' getting obese after retiring from the field is due to their having gotten used to high caloric intake and expenditures, but maybe their brown fat goes away as well. The purpose of brown fat in neonates and hibernating animals is to maintain body temperature. Unlike typical fat cells, brown fat cells are derived from the same anlage as muscle. They are brown because of their high mitochrondia concentrations. When faced with a hypothermic environment, they produce heat to prevent hypothermia. Brown fat was thought to be absent in adults until early in this century. I now have exhaused my knowledge of brown fat. |
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Re: Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
posted at 29/1/2012 12:59 PM GMT
on bmj.com
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Posts: 277
First: 13/4/2010 Last: 16/5/2012 |
Brown fat is an old story - around for at least 30 years when I learned we are born with a lot of brown fat. The story went that because we lived in a cold climate (at least here in northern Europe) these brown fat cells were in a hypermetabolic state trying to keep us warm and thus kept us thin,. When central heating, efficient clothing and lack of exercise became the norm these brown fat cells were no longer needed and thus their hyper-metabolic function was diminsihed and we became more obese. Probably compete bulls**t but sounds like a good story. |
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Re: Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
posted at 29/1/2012 4:45 PM GMT
on bmj.com
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Posts: 142
First: 29/4/2011 Last: 14/5/2012 |
Could be, but I'll put my money on fast foods and sedentary life style. Evolutionary changes occur slowly and the obesity epidemic started in 1970. |
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Re: Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
posted at 30/1/2012 12:27 PM GMT
on bmj.com
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Posts: 277
First: 13/4/2010 Last: 16/5/2012 |
Agree with you diabetes MD - that's why I used the word "story". I share your view - what has changed is our consumption of sugar and refined carbohydrates. That coupled with an increasing sedintary lifestyle is what is driving the obesity epidemic. As a primary care physician I try to get this message across but I am hamstrung to some extent by the continued emphasis from people like the British Heart Foundation or Diabetes UK who continue to push the idea that dietry fat is the root of all evil when the evidence to back that up is just not there whereas the evidence for sugars and refined carbohydrates is almost overwhelming but consistently ignored. As I tell my own kids, if you are going to eat a burger throw away the bun and the sauce first and just eat the meat and salad! |
Forums » Open clinical » Diabetes » Why "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis" is an important article
