Diabetes type 3. What?
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Diabetes type 3. What?
Discuss any aspect of type I or type II diabetes mellitus here
Diabetes gurus, I'm getting referrals for pre-op. assessement from surgeons alarmed by a diagnosis of "type 3 diabetes" Me, too. I have googled and found three different d
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Cat:OpenClinicalForum:209c1fee-a6e1-4cf9-9bd5-7d4dd5443e39
Cat:OpenClinicalForum:209c1fee-a6e1-4cf9-9bd5-7d4dd5443e39Discussion:2e76b0b7-6f9e-41ff-955b-d63fc85af2d1
Forums » Open clinical » Diabetes » Diabetes type 3. What?
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Re: Diabetes type 3. What?
posted at 29/11/2011 10:53 AM GMT
on bmj.com
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Posts: 7
First: 22/11/2011 Last: 30/11/2011 |
Diabetes type 1 and type 2 are very common which are caused from the decline of insulin production within the pancreas to the point where there is no insulin produced. But then scientists found that insulin is also produced within the brain. So if explained simply, Dibetes type 3 is caused when the brain stops or reduces the acceptance of the brain's secreted insulin. |
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Re: Diabetes type 3. What?
posted at 7/12/2011 2:48 PM GMT
on bmj.com
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Posts: 624
First: 13/4/2011 Last: 15/5/2013 |
Hello Fellows: There is indeed some people relating Alzheimer Disease as a form of "brain type 3 Diabetes". The researcher who has been mostly studying this is Suzanne M. de la Monte. This is completely new for me. So, I will have to take a deeper look at it. I appreciate if anybody would let us know more about it Eric Steen, Benjamin M. Terry, Enrique J. Rivera, Jennifer L. Cannon, Thomas R. Neely, Rose Tavares, X. Julia Xu, Jack R. Wands, Suzanne M. de la Monte Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease---is this type 3 diabetes? Abstract: The neurodegeneration that occurs in sporadic Alzheimer’s disease (AD) is consistently associated with a number of characteristic histopathological, molecular, and biochemical abnormalities, including cell loss, abundant neurofibrillary tangles and dystrophic neurites, amyloid-β deposits, increased activation of pro-death genes and signaling pathways, impaired energy metabolism/mitochondrial function, and evidence of chronic oxidative stress. The general inability to convincingly link these phenomena has resulted in the emergence and propagation of various heavily debated theories that focus on the role of one particular element in the pathogenesis of all other abnormalities. However, the accumulating evidence that reduced glucose utilization and deficient energy metabolism occur early in the course of disease, suggests a role for impaired insulin signaling in the pathogenesis of AD. The present work demonstrates extensive abnormalities in insulin and insulin-like growth factor, types I and II (IGF-I and IGF-II) signaling mechanisms in brains with AD, and shows that while each of the corresponding growth factors is normally made in central nervous system (CNS) neurons, the expression levels are markedly reduced in AD. These abnormalities were associated with reduced levels of insulin receptor substrate (IRS) mRNA, tau mRNA, IRS-associated phosphotidylinositol 3-kinase, and phospho-Akt (activated), and increased glycogen synthase kinase-3β activity and amyloid precursor protein mRNA expression. The strikingly reduced CNS expression of genes encoding insulin, IGF-I, and IGF-II, as well as the insulin and IGF-I receptors, suggests that Alzheimer`s Disease may represent a neuro-endocrine disorder that resembles, yet is distinct from diabetes mellitus. Therefore, we propose the term, “Type 3 Diabetes” to reflect this newly identified pathogenic mechanism of neurodegeneration. All Best, Joey
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Re: Diabetes type 3. What?
posted at 8/12/2011 9:19 AM GMT
on bmj.com
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Posts: 624
First: 13/4/2011 Last: 15/5/2013 |
For those interested here goes the complete article about this "brain" diabetes. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease – is this type 3 diabetes? All Best, Joey
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Re: Diabetes type 3. What?
posted at 4/1/2012 9:47 AM GMT
on bmj.com
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Posts: 4
First: 4/1/2012 Last: 2/4/2012 |
There are mostly 2 types of diabetes type 1 diabetes and type 2 diabetes. I never heard about type 3 diabetes. This is the post is very good to know more about type 3 diabetes. I am also a diaebetic person and like to thanks for sharing this information. What is Type 1 Diabetes |
Forums » Open clinical » Diabetes » Diabetes type 3. What?
