{macro question(showVoteTotal)}
    <div class="poll-question">
      {if keyType == "discussion"}
        <a href="/forums/?plckForumPage=ForumDiscussion&plckDiscussionId=${key}#forumPostTitle_1" title="View discussion">
          ${poll.Question}
        </a>
      {else}
        ${poll.Question}
      {/if}
      {if showVoteTotal}
        <span class="poll-votes">(${poll.TotalVotes} ${"vote"|pluralise:poll.TotalVotes})</span>
      {/if}
    </div>
  {/macro}
  <div class="slResults" {if !noVote}style="display:none;"{/if}>
    ${question(true)}
    <table class="slAnswerStats" cellpadding="0" cellspacing="0" border="0">
      {for answer in poll.Answers}
        <tr class="slAnswerStat slAnswerStat_${answer_index}">
          <td class="slAnswer">${answer.Answer}</td>
          <td class="slAnswerBarCell">
            <div class="slAnswerBar">
              <div class="slAnswerCount">${answer.NumberOfVotes} ${"vote"|pluralise:answer.NumberOfVotes} (${answer.PercentageStr}%)</div>
              <div class="slAnswerBarPercent" style="width: ${answer.Percentage}%;"></div>
            </div>
          </td>
        </tr>
      {/for}
    </table>
    {if !noVote}<div class="results"><a href="javascript:void(0);" class="slVoteLink">Go vote!</a></div>{/if}
  </div>

{if !noVote}
  <div class="slVote">
    <div class="slErrorText">You must select one answer before submitting your vote.</div>
    ${question(false)}
    <table class="slAnswers" cellspacing="0" cellpadding="0" border="0">
      {for answer in poll.Answers}
        {var answerId = poll.PollKey.Key + '.' + answer_index}
        <tr>
          <td class="slAnswerInput">
            <input type="radio" name="answers" value="${answer_index}" id="${answerId}"/>
          </td>
          <td class="slAnswerText">
            <label for="${answerId}">${answer.Answer}</label>
          </td>
        </tr>
      {/for}
    </table>
    <div style="clear: both; margin-left: 8px;">
      <div class="slSendAnswer"><input class="slVoteButton" type="button" value="Vote" /></div>
      <div class="results"><a href="javascript:void(0);" class="slResultsLink">View Results...</a></div>
    </div>
  </div>
  {/if}

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Are all sulphonyureas equal?

False

Cardiology

Are all sulphonyureas equal?

Read and join discussion threads related to cardiology

I noticed a study presented at the European Association of Diabetes meeting suggests that glyburide use is associated with more ACS presentations than gliclazide. http://www.theheart.org/article/14544

0

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Cat:OpenClinicalForum:083a12c9-861a-4a42-a5af-ddc3263b34bcDiscussion:8fefe0a4-81ec-4838-9381-62bc0da63ee0

Forums » Open clinical » Cardiology » Are all sulphonyureas equal?

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Forums » Open clinical » Cardiology » Are all sulphonyureas equal?

Are all sulphonyureas equal?

posted at 16/10/2012 3:15 PM BST on bmj.com

sadian

Posts: 873
First: 17/6/2011
Last: 17/5/2013

I noticed a study presented at the European Association of Diabetes meeting suggests that glyburide use is associated with more ACS presentations than gliclazide.
http://www.theheart.org/article/1454487.do?utm_medium=email&utm_source=20121013_EASD&utm_campaign=newsletter
I've got no experience with glyburide - does anyone prescribe this and is this study result explained by confounding?
sadian

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Re: Are all sulphonyureas equal?

posted at 16/10/2012 6:12 PM BST on bmj.com

Dr. K. Ashutosh

Posts: 3031
First: 27/3/2012
Last: 11/5/2013

Glyburide in India is available as Daonil.
This is also called as glibenclamide. Glibenclamide is the most potent oral hypoglycemic agent with longest half life & cumulative toxicity & is known to be associated with increased episodes of ACS. Hence should not be prescribed in elderly considering the fact that most of the sudden deaths in diabetic patients are due to hypoglycemia.

New post Reply to this post

Re: Are all sulphonyureas equal?

posted at 18/10/2012 2:52 PM BST on bmj.com

Sachin India

Posts: 22
First: 3/8/2011
Last: 18/5/2013

apart from CV risk profile, they also differ in tendency to cause hypoglycemia, maximum with Glyburide ( glibenclamide) and least eith Glimepiride.

i feel the reason behind could be effect glucagon suppression, least with glimipride and max with glibenclamide.

this could also be the reason behind why glimepiride fails to acheive glycemic control in T2DM patients > 10 yrs old on therapy, in whom glibenclamide score better.

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Re: Are all sulphonyureas equal?

posted at 23/12/2012 7:51 PM GMT on bmj.com

Joey Rio

Posts: 624
First: 13/4/2011
Last: 15/5/2013

I find Gliclazide the most safe and user friendly sulfonylurea.

I has a short half-life, but can be given once-daily with its extended dose release tablets, and have a wide dose range. And it is not expensive

There is also good and long-term clinical trial data supporting its use (the ADVANCE Study).

So, it is my number one sulfonylurea.

All Best,

Joey

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Forums » Open clinical » Cardiology » Are all sulphonyureas equal?