{macro question(showVoteTotal)}
    <div class="poll-question">
      {if keyType == "discussion"}
        <a href="/forums/?plckForumPage=ForumDiscussion&plckDiscussionId=${key}#forumPostTitle_1" title="View discussion">
          ${poll.Question}
        </a>
      {else}
        ${poll.Question}
      {/if}
      {if showVoteTotal}
        <span class="poll-votes">(${poll.TotalVotes} ${"vote"|pluralise:poll.TotalVotes})</span>
      {/if}
    </div>
  {/macro}
  <div class="slResults" {if !noVote}style="display:none;"{/if}>
    ${question(true)}
    <table class="slAnswerStats" cellpadding="0" cellspacing="0" border="0">
      {for answer in poll.Answers}
        <tr class="slAnswerStat slAnswerStat_${answer_index}">
          <td class="slAnswer">${answer.Answer}</td>
          <td class="slAnswerBarCell">
            <div class="slAnswerBar">
              <div class="slAnswerCount">${answer.NumberOfVotes} ${"vote"|pluralise:answer.NumberOfVotes} (${answer.PercentageStr}%)</div>
              <div class="slAnswerBarPercent" style="width: ${answer.Percentage}%;"></div>
            </div>
          </td>
        </tr>
      {/for}
    </table>
    {if !noVote}<div class="results"><a href="javascript:void(0);" class="slVoteLink">Go vote!</a></div>{/if}
  </div>

{if !noVote}
  <div class="slVote">
    <div class="slErrorText">You must select one answer before submitting your vote.</div>
    ${question(false)}
    <table class="slAnswers" cellspacing="0" cellpadding="0" border="0">
      {for answer in poll.Answers}
        {var answerId = poll.PollKey.Key + '.' + answer_index}
        <tr>
          <td class="slAnswerInput">
            <input type="radio" name="answers" value="${answer_index}" id="${answerId}"/>
          </td>
          <td class="slAnswerText">
            <label for="${answerId}">${answer.Answer}</label>
          </td>
        </tr>
      {/for}
    </table>
    <div style="clear: both; margin-left: 8px;">
      <div class="slSendAnswer"><input class="slVoteButton" type="button" value="Vote" /></div>
      <div class="results"><a href="javascript:void(0);" class="slResultsLink">View Results...</a></div>
    </div>
  </div>
  {/if}

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Should we just ditch simvastatin?

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Cardiology

Should we just ditch simvastatin?

Read and join discussion threads related to cardiology

The list of interactions with simvastatin grows and the number of dose reductions increases! http://www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safetywarningsandmessagesformedicin

0

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Forums » Open clinical » Cardiology » Should we just ditch simvastatin?

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Forums » Open clinical » Cardiology » Should we just ditch simvastatin?

Should we just ditch simvastatin?

posted at 1/11/2012 10:12 AM GMT on bmj.com

sadian

Posts: 873
First: 17/6/2011
Last: 17/5/2013

The list of interactions with simvastatin grows and the number of dose reductions increases!
http://www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safetywarningsandmessagesformedicines/CON199556
Should we just go with atorvastatin given it is now generic and 'forget' simva?
sadian

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Re: Should we just ditch simvastatin?

posted at 7/11/2012 10:17 AM GMT on bmj.com

doctorg

Posts: 58
First: 24/10/2011
Last: 9/5/2013

I do not think we should be too quick to ditch Simvastatin. It is still cheaper than atorvastatin (roughly £1:50/month compared with £2:26). I am on it myself, and, although I have some increased muscle fatigue (vey mild) it lowers my cholesterol significantly more than other statins that I have tried.

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Re: Should we just ditch simvastatin?

posted at 7/11/2012 12:46 PM GMT on bmj.com

skyesteve

Posts: 1259
First: 13/4/2010
Last: 19/5/2013

As above - stick with simva until atorva as cheap/cheaper

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Re: Should we just ditch simvastatin?

posted at 7/11/2012 7:37 PM GMT on bmj.com

TimReynolds

Posts: 321
First: 12/11/2010
Last: 8/5/2013

The reason Simva now has so many recorded interactions is that it has been around for a long time so people have had a chance to report them. Atorvastatin will have as many / more because it uses several other cytochromes and has a longer half life. The main thing to do is avoid Simva 80 - If you need that much use something different.

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Re: Should we just ditch simvastatin?

posted at 8/11/2012 6:51 PM GMT on bmj.com

yoram chaiter

Posts: 1784
First: 7/3/2009
Last: 18/5/2013

The reasoning of which is cheaper is not a medical one.

What is "cheaper"? The medication? How about the side effects of simvastatin? They do not cause expenses? The important effect is the therapeutic effect.

There are ways to determine a certain polymorphism that makes one more susceptible to muscle damage from simvastatin, but it is not used yet widely.

In this situation, I believe atovastatin would make a better first choice, since it has less side effects.Even if it is more expensive.

New post Reply to this post

Re: Should we just ditch simvastatin?

posted at 8/11/2012 7:30 PM GMT on bmj.com

TimReynolds

Posts: 321
First: 12/11/2010
Last: 8/5/2013

Atorva has as many side effects as Simva - and as many interactions. Also, it is not currently on sale as a generic so still costs £26 (approx) / month compared with simva at £3 / month [according to Sept 2012 BNF]

New post Reply to this post

Re: Should we just ditch simvastatin?

posted at 23/12/2012 7:43 PM GMT on bmj.com

Joey Rio

Posts: 624
First: 13/4/2011
Last: 15/5/2013

Dear All:

Atorvastatin has been around for many and many years with fewer side-effects, and more potency than Simvastatin.

And it is generic everywhere in this world because its 10 years of patented drug is already done for a while.

All Best,

Joey

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Re: Should we just ditch simvastatin?

posted at 24/12/2012 9:14 AM GMT on bmj.com

gramanathan

Posts: 12
First: 20/1/2012
Last: 5/1/2013

Simvastatin at lower dosage i.e 20mg is alright. If a higher dosage is reguired then atorvastatin should be preferred.

Sincerely, Gunasagaran

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Forums » Open clinical » Cardiology » Should we just ditch simvastatin?