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Secret of Anaesthesia Revealed?
posted at 27/10/2012 8:54 PM BST
on bmj.com
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Posts: 3037
First: 27/3/2012 Last: 18/5/2013 |
General anesthesia drugs really do put patients to sleep, suggests research conducted in mice. Although the research with mice was revealing, experts also note that animal experiments don't always produce the same results when applied to human subjects. The study found that the drugs don't just turn wakefulness off, they also switch on important sleep circuits in the brain, according to the findings, which were published online Oct. 25 in the journal Current Biology. There are important differences between natural sleep and the unconscious state caused by general anesthesia. Even the soundest sleeper can be awakened, but anesthetized patients remain unconscious throughout the trauma inflicted on their bodies during surgery. Link: http://www.nlm.nih.gov/medlineplus/news/fullstory_130663.html |
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Re: Secret of Anaesthesia Revealed?
posted at 28/10/2012 6:17 PM GMT
on bmj.com
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Posts: 2035
First: 12/3/2010 Last: 19/5/2013 |
Thanks, Dr.Ashutosh! Here's a summary of the original paper, as I don't have access to "Current Biology": http://www.cell.com/current-biology/abstract/S0960-9822(12)01007-X I'm none the wiser after reading it than I was from your excellent post, and yes, we really don't know, in deep terms, how anaesthetics work. Nor are we, even if we can point to where some of them work. There are so many molecules that are anaesthetic, from the complex steroids of the outdated IV drug Althesin, through the halogenated hydrocarbons like isoflurane, to Xenon, a Noble Gas for goodness sake, that cannot take part much in the way of chemical reactions! While that's frustrating, as it gives us no great pointers towards new and better drugs, it does show, if I may say so, how important is the clinical vigilance of the anaesthetist. John |
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Re: Secret of Anaesthesia Revealed?
posted at 28/10/2012 6:52 PM GMT
on bmj.com
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