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Secret of Anaesthesia Revealed?
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Secret of Anaesthesia Revealed?
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General anesthesia drugs really do put patients to sleep, suggests research conducted in mice. Although the research with mice was revealing, experts also note that animal experiments don't always pr
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Secret of Anaesthesia Revealed?

posted at 27/10/2012 8:54 PM BST on bmj.com
Posts: 3037
First: 27/3/2012
Last: 18/5/2013

General anesthesia drugs really do put patients to sleep, suggests research conducted in mice. Although the research with mice was revealing, experts also note that animal experiments don't always produce the same results when applied to human subjects.

The study found that the drugs don't just turn wakefulness off, they also switch on important sleep circuits in the brain, according to the findings, which were published online Oct. 25 in the journal Current Biology. There are important differences between natural sleep and the unconscious state caused by general anesthesia. Even the soundest sleeper can be awakened, but anesthetized patients remain unconscious throughout the trauma inflicted on their bodies during surgery.

Link: http://www.nlm.nih.gov/medlineplus/news/fullstory_130663.html

Re: Secret of Anaesthesia Revealed?

posted at 28/10/2012 6:17 PM GMT on bmj.com
Posts: 2035
First: 12/3/2010
Last: 19/5/2013
Thanks, Dr.Ashutosh!

Here's a summary of the original paper, as I don't have access to "Current Biology":
http://www.cell.com/current-biology/abstract/S0960-9822(12)01007-X

I'm none the wiser after reading it than I was from your excellent post, and yes, we really don't know, in deep terms, how anaesthetics work.  Nor are we, even if we can point to where some of them work.   There are so many molecules that are anaesthetic, from the complex steroids of the outdated IV drug Althesin, through the halogenated hydrocarbons like isoflurane, to Xenon, a Noble Gas for goodness sake, that cannot take part much in the way of chemical reactions!
    While that's frustrating, as it gives us no great pointers towards new and better drugs, it does show, if I may say so, how important is the clinical vigilance of the anaesthetist.

John

Re: Secret of Anaesthesia Revealed?

posted at 28/10/2012 6:52 PM GMT on bmj.com
Posts: 3037
First: 27/3/2012
Last: 18/5/2013
Thanks respected John for providing me the original abstract.
I do agree that anesthesiologist has the most important clinical role in any surgery & hats off for their excellence in the skills!

Forums » Off duty » News & media » Secret of Anaesthesia Revealed?