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A team of international researchers have analysed genetic data of 50,000 Europeans,and a significant association of migraine was linked to mutations in chromosome nomber 8 , genes loci PGCP and
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Migraine
posted at 2/2/2012 10:48 PM GMT
on bmj.com
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Posts: 132
First: 2/8/2010 Last: 11/5/2012 |
A team of international researchers have analysed genetic data of 50,000 Europeans,and a significant association of migraine was linked to mutations in chromosome nomber 8 , genes loci PGCP and MTDH/AEG-1 It is interesting that the effect of this genetic variation appeared to be stronger in people who have migraine with visual disturbances, aura, than in people who have migraine without auras. Gene therapy could play an important role for the treatment of migraine in the near future |
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Re: Migraine
posted at 3/2/2012 2:06 PM GMT
on bmj.com
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*Moderator*
Posts: 593
First: 17/11/2008 Last: 15/5/2012 |
Ah I have an aura and visual disturbances so can you let me know the ref for this. Not that I can do anything about my genetic make up but I am interested I am also interested in how you make sense of this- how many associations with mutations are later thought not to be meaningful in the same way that associations in other areas of medicine are later thought to be meaningless. |
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Re: Migraine
posted at 3/2/2012 2:48 PM GMT
on bmj.com
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Posts: 5
First: 28/3/2011 Last: 24/2/2012 |
Are there any doctors/medical students/pre-meds who also suffer from Migraines?If so, do you declare it when applying for medical jobs,...etc? I'm intereseted to know if it impedes your chances of getting a competitive job or secure a place at a medical school in the first place. Of course one should be manageing their migraines properly and idealy shouldn't be having an attack frequently, otherwise the illness would be disabling and one cannot carry their duty. But, just the fact that you have it and declare it, does it lower your chances? I'm interested to read your thoughts. |
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Re: Migraine
posted at 3/2/2012 8:38 PM GMT
on bmj.com
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Posts: 132
First: 2/8/2010 Last: 11/5/2012 |
In Response to Re: Migraine: Ah I have an aura and visual disturbances so can you let me know the ref for this. Not that I can do anything about my genetic make up but I am interested I am also interested in how you make sense of this- how many associations with mutations are later thought not to be meaningful in the same way that associations in other areas of medicine are later thought to be meaningless. Posted by luisad Being very optimistic on the future of gene therapy I did many searches in the area of migraine, Although early clinical failures led many to dismiss gene therapy as over-hyped, clinical successes in 2009-2011 have bolstered new optimism in the promise of gene therapy, these include successful treatment of patient with parkinsonism, X-linked severe combined immune defficiency, adrenoleucodystrophy....etc Migraine is still a new developing area of researches, and inspite of the contradictory results obtained so far, but there is a defenitive genetic link which is indisputable You can visit the links below , including www.pubmed.com ( ? open access ) 1/ http://www.webmd.com/migraines-headaches/news/20100830/first-genetic-link-to-common-migraine-found 2/ Eur J Neurol. 2011 Nov 22. doi: 10.1111/j.1468-1331.2011.03588.x. [Epub ahead of print] 3/ J Headache Pain. 2012 Jan;13(1):1-9. Epub 2011 Nov 11. |
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Re: Migraine
posted at 3/2/2012 9:18 PM GMT
on bmj.com
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Posts: 132
First: 2/8/2010 Last: 11/5/2012 |
In Response to Re: Migraine: Are there any doctors/medical students/pre-meds who also suffer from Migraines?If so, do you declare it when applying for medical jobs,...etc? I'm intereseted to know if it impedes your chances of getting a competitive job or secure a place at a medical school in the first place. Of course one should be manageing their migraines properly and idealy shouldn't be having an attack frequently, otherwise the illness would be disabling and one cannot carry their duty. But, just the fact that you have it and declare it, does it lower your chances? I'm interested to read your thoughts. Posted by Maymona I do not think migraine can interfer with doctors work, nor students to get into medical schools, I have many colleagues with migraine working perfectly and the GMC knows about it, unless it is a crippling type limiting one`s movement and activities then it should be alright |
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Re: Migraine
posted at 31/3/2012 11:11 AM BST
on bmj.com
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Posts: 1
First: 31/3/2012 Last: 31/3/2012 |
amitriptyline hydrochloride composition tabs are useful for primary stage migraine?????is there any other way to relieve form this pain which does nt includes pharma medication...i mean to say that we can get rid of this migraine by yoga or something else???? |
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Re: Migraine
posted at 8/4/2012 9:46 PM BST
on bmj.com
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*Moderator*
Posts: 593
First: 17/11/2008 Last: 15/5/2012 |
NICE are currently still writing a guideline about headaches including migraine but SIGN have one- they are very very good- the scottish equivalent of NICE in terms of quality of guidelines.http://www.sign.ac.uk/guidelines/fulltext/107/index.html Hope is it useful |
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Re: Migraine
posted at 9/4/2012 10:40 AM BST
on bmj.com
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Posts: 277
First: 13/4/2010 Last: 16/5/2012 |
Hi Alaminium - I am glad you are optimistic about gene therapy because I certainly am not and regard it as something of a false dawn (although I profoundly hope to be proved wrong, sooner rather than later). |
