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I like Cochrane, HTA and NICE meta-analyses because they have done all the work for me BUT when they publish on a subject I have some expertise on I find they that they produce (without exception) the wrong conclusion.
I once met the head of NHS innovation after he lectured us on their adoption roadmap for new medical devices. I took him out for coffee, explained why in real life the roadmap did not work. For his benefit I then emailed 12 heads of department in NHS hospitals and they all declared that they had not implemented any advice from Cochrane, NICE or HTA. One was a reviewer for Cochrane and she said that the way she was required to score papers for review meant that she ended up recommending procedures that she would never use on her own patients.