Blogs by the online BMJ diabetes champions and guests
In Defence of the "Magic" Anti-Obesity and Diabetic Pill
No, I am not talking about any of those highly promoted, and still unsafe, oral or parenteral, so-called incretin-based anti diabetic drugs.
I am talking about a combination pill manufacturaded by a small pharmaceutical company (to which I hold no interest conflict) that early on its therapeutic course of actions make patients loose 5 to 10% of body weight, lower waist circumference, lower blood pressures and lower HBA1C levels, with a quite reasonable safety and side-effects profile.
This new drug is a combination of Topiramate with Phentermine. The brand name is Qnexa.
The use of both agents provides a treatment option that is more efficacious than anything currently in the market for loosing body weight.
There are multiple neuronal and peripheral pathways implicated in the regulation of energy homeostasis, food intake and saciety. This combination pill seems to overcome this complex circuitry.
"The combination of phentermine and topiramate is an
effective adjunct to diet and lifestyle modification for weight
loss and measures of comorbidity in overweight or obese
adults with additional metabolic risk factors"
Don´t you think we should allow a fair chance for this kind of drug???
A Hoosier Doc returns to China 1
Insulin Pumps in the Hospital Setting
Treatment of hyperglycemia in the hospitalized setting
Is there a role for agents affecting the GLP-1 system in treatment of type 2 DM today? NO
Shall we adopt the KDIGO 2012 chronic kidney disease guidelines for the management of type 2 diabetics with chronic nephropathy?